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Lymphangioleiomyomatosis
1 OMIM reference -
2 associated genes
36 signs/symptoms
PROTEIN INTERACTIONS: 1
COMMON SIGNS: 2
Mantle cell lymphoma
3 associated genes
7 signs/symptoms
Lymphangioleiomyomatosis
Mantle cell lymphoma

TSC1
(UniProt - OMIM)
 ATM
(UniProt - OMIM)
TSC2
(UniProt - OMIM)
 CCND1
(UniProt - OMIM)
IGH
(UniProt)

INTERACTOME
ASSOCIATIONS
(click on a score value to see the evidence)
TSC2
(0.73)
CCND1


Citations in the biomedical literature:


Lymphangioleiomyomatosis
TSC1 TSC2
Mantle cell lymphoma
ATM CCND1 IGH



Lymphangioleiomyomatosis
Mantle cell lymphoma

Synonym(s):
- LAM
Synonym(s):
- LCM
- MCL
- Mantle zone lymphoma
Classification (Orphanet):
- Rare genetic disease
- Rare respiratory disease
Classification (Orphanet):
- Rare hematologic disease
- Rare oncologic disease
Classification (ICD10):
- Diseases of the respiratory system -
Classification (ICD10):
- Neoplasms -
Epidemiological data:
Class of prevalence: 1-9 / 1 000 000
Average age onset: adulthood
Average age of death: -
Type of inheritance: sporadic
Epidemiological data:
Class of prevalence: 1-9 / 100 000
Average age onset: adulthood
Average age of death: adult
Type of inheritance: multigenic/multifactorial
External references:
1 OMIM reference -
1 MeSH reference: D018192
External references:
No OMIM references
1 MeSH reference: D020522
COMMON
SIGNS 		- Asthenia / fatigue / weakness
- Lymphadenopathy / polyadenopathies

Lymphangioleiomyomatosis
Mantle cell lymphoma

Very frequent
- Anomalies of the lymphatic system
- Cough
- Interstitial / restrictive pneumopathy / restrictive respiratory syndrome
- Lung / pulmonary infiltrates
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction
- Thoracic / chest pain

Frequent
- Acute abdominal pain / colic
- Atelectasia / pulmonary collapse
- Cutaneous neurofibromas / facial angiofibromas / Koenen tumors
- Emphysema
- Hematuria / microhematuria
- Multicystic kidney / renal dysplasia
- Ungual / paraungual fibromas (fingernails)
- Uterine / uterus / Fallopian tubes anomalies

Occasional
- Abnormal colour of the urine / cholic / dark urines
- Abnormal pigmentary skin changes / skin pigmentation anomalies
- Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax
- Anomalies of eyelids, eyelashes and lacrimal system
- Ascitis
- Fever / chilling
- Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia
- Hemoptysis
- Hydrocephaly
- Intellectual deficit / mental / psychomotor retardation / learning disability
- Kidney / renal neoplasm / tumor / carcinoma / cancer
- Lymphedema
- Macules
- Optic nerve anomaly / optic atrophy / anomaly of the papilla
- Pericardium anomalies / pericarditis / absence / cysts / pericardial effusion
- Polycystic kidneys
- Repeat respiratory infections
- Retinal hamartoma
- Seizures / epilepsy / absences / spasms / status epilepticus
- Shagreen patch


Very frequent
- Hematologic / blood / lymphatic cancer

Frequent
- Anorexia
- Bone marrow / medullar infiltration
- Splenomegaly
- Weight loss / loss of appetite / break in weight curve / general health alteration